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Dave Thirumalai
Friday, March 15, 2019, 02:30pm - 03:30pm
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Contact Ken Dill
Department of Chemistry
University of Texas at Austin

Interphase Human Chromosome Exhibits Out of Equilibrium Glassy Dynamics

The structural organization of the condensed chromosomes is being revealed using chromosome conformation capture experiments and super-resolution imaging techniques. Fingerprints of their three-dimensional organization on length scale from about hundred kilo base pairs to millions of base pairs have emerged using advances in Hi-C and super-resolution microscopy.  I will describe using a minimal Chromosome Copolymer Model (CCM) with two loci types corresponding to euchromatin and heterochromatin that the dynamics is similar to that observed in glasses. Chromosome organization is hierarchical involving the formation of chromosome droplets (CDs) on short genomic scale followed by coalescence of the CDs, reminiscent of Ostwald ripening. Glassy landscapes for the condensed active chromosomes might provide a balance between genomic conformational stability and biological functions.
Location Laufer Center Lecture Hall 101
Refreshments following lecture in Laufer Hub 110