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Saeed Tavazoie
Friday, May 10, 2019, 02:30pm - 03:30pm
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Contact Ken Dill
Professor
Department of Biochemistry & Molecular Biophysics
and Department of Systems Biology
Columbia University
 
ST
 
Gene regulation beyond the standard model: Adaptive reprogramming of gene expression by trial and error.
 
I will discuss our recent evidence for a previously undescribed mechanism by which cells can achieve adaptive gene expression states using a health optimization strategy we call stochastic tuning. This process enables cells to adapt to unfamiliar or extreme environments where their conventional hard-coded regulatory systems no longer adequately function. I will discuss the implications of this phenomenon for our basic understanding of gene regulation and cellular adaptation.
 
Location Laufer Center Lecture Hall 101
Refreshments following lecture in Laufer Hub 110