Events Calendar

By Year By Month By Week Jump to month
Cancelled Kevin Chen
Friday, March 27, 2015, 02:30pm - 03:30pm
Hits : 560
Contact Host: Sasha Levy
Kevin C. Chen
Department of Genetics and BioMaPS Institute
Rutgers
 
 

Predicting enhancer elements from human epigenomics data by spectral learning of Hidden Markov Models.

Since 93% of disease-related variants in the human genome reside outside of protein coding genes, it is important to develop computational techniques to predict which of these variants are most likely to be causal for the disease. Our group mainly uses computational techniques to interpret variation in the genome that affects the function of non-coding RNAs and gene regulatory elements. In this talk, I will describe our recent results on extending and implementing a novel class of spectral learning algorithms for Hidden Markov Models and related graphical models, with the goal of segmenting the genome into distinct chromatin domains, such as different enhancer subtypes. In several cell types, we find that disease-associated variants from genome-wide association studies are most strongly enriched in enhancer elements found by our method, Spectacle.

 

Location Laufer Center Lecture Hall 101