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Yu (Brandon) Xia
Tuesday, September 11, 2012, 04:00pm - 05:00pm
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Laufer Center Seminar

Yu (Brandon) Xia

Assistant Professor, Chemistry, and Bioinformatics Graduate   Program

Boston University

Biological networks in three dimensions

Two studies are highlighted where three-dimensional modeling of
protein networks within and between species provides insights into the
biophysics and evolution of biological systems. First, a structural
analysis of the yeast protein-protein interaction network reveals that
protein evolution is constrained by the biophysics of protein folding,
the mutational robustness of the native structure, and the biophysics
and function of protein-protein interactions. Second, a structural
analysis of human-virus protein-protein interaction networks reveals
distinct principles governing antagonism versus cooperation in
host-pathogen and within-host interactions