Nov. 15, 2024 LC Seminar

Benjamin Lin, PhD

Assistant Professor, Cell dynamics and motility
Biochemistry & Cell Biology
Stony Brook University

Talk Title: "Deconstructing amoeboid cell migration in vivo”

Abstract: Individual cells migrate in complex 3D environments to form organs, hunt down pathogens, and heal wounds in vivo. Yet, much of what we know about cell migration has come from observing cells on 2D substrates in vitro. In 2D environments, cells generally move by extending a dynamic branched actin-filled leading edge. However, cells in 3D developing animals and tumors can use an alternative, poorly understood cell movement strategy called amoeboid migration. I will describe our studies using Drosophila primordial germ cells (PGCs) as a new model system to uncover molecular mechanisms underlying guided amoeboid migration in vivo.

Host: Ivet Bahar

Location: Laufer Center Lecture Hall 101, 12 PM