DrugDisc

A novel strategy for treating immune-suppressive breast cancer: pharmacological prevention of CD73 deubiquitination (Zhu et al., J Clinical Investigation 2024)

A novel strategy for treating immune-suppressive breast cancer: pharmacological prevention of CD73 deubiquitination (Zhu et al., J Clinical Investigation 2024)

Allosteric modulation of parathyroid hormone receptor (PTHR) for regulating calcium signaling and endocrine homeostasis (Sutkeviciute et al Nature Chem Biol, 2022)

Allosteric modulation of parathyroid hormone receptor (PTHR) for regulating calcium signaling and endocrine homeostasis (Sutkeviciute et al Nature Chem Biol, 2022)

Recognition of SARS-CoV-2 spike superantigenic segment by T cell receptors (Cheng et al., PNAS 2020)

Recognition of SARS-CoV-2 spike superantigenic segment by T cell receptors (Cheng et al., PNAS 2020)

Targeting Cyt c peroxidase activity by imidazole substituted fatty acids for treating Barth syndrome (Kagan et al., Nature Metabolism, 2024)

Targeting Cyt c peroxidase activity by imidazole substituted fatty acids for treating Barth syndrome (Kagan et al., Nature Metabolism, 2024)

Development of new methodology for pharmacophore modeling: Pharmmaker (Lee et al. Protein Sci 2020)

Development of new methodology for pharmacophore modeling: Pharmmaker (Lee et al. Protein Sci 2020)

Design of small molecule activators of protein phosphatase (PP2A) - a tumor suppressor protein

Design of small molecule activators of protein phosphatase (PP2A) - a tumor suppressor protein

Targeting of allosteric sites as a strategy for complementing orthosteric site targeting and alleviating drug resistance

Targeting of allosteric sites as a strategy for complementing orthosteric site targeting and alleviating drug resistance

Design, synthesis and characterization of positive allosteric modulators (PAMs) of excitatory amino acid transporter 2 (EAAT2) (Fontana et al. J Med Chem, 2024)

Design, synthesis and characterization of positive allosteric modulators (PAMs) of excitatory amino acid transporter 2 (EAAT2) (Fontana et al. J Med Chem, 2024)