LC Seminar - Sergey Kryazhimskiy
Sergey Kryazhimskiy, PhD
Associate Professor
Department of Ecology, Behavior & Evolution
UC San Diego
Friday, January 23, 2026 in LC 101 at 12:30 PM
Talk Title: Global epistasis and some side effects of adaptation
Abstract: Adaptive evolution can lead to profound changes in the phenotypes and behaviors of
biological systems, with adverse or beneficial consequences. However, predicting these
changes remains difficult. One major challenge is that how new mutations alter
phenotypes and fitness of organisms often depends on the genetic background in which
they arise (G×G interactions or “epistasis”), the environment (G×E interactions), or both
(G×G×E interactions). In this talk, I will discuss our recent experimental efforts to measure
these interactions in budding yeast and some implications of our findings for evolutionary
dynamics.
Gabor Balazsi, host
