Laufer Center Spring Retreat

The Old Field Club

86 West Meadow Road

Setauket, New York, 117331

Tuesday, April 22, 2025

*By invitation only

Check-in & Continental Breakfast 8:30 – 9:00

Morning Session 9:00 – 12:00

9:00 - Dr. Ivet Bahar, Opening remarks and Center Overview and Introductions

9:30 – Todd Miller, Plenary Speaker, Mechanisms of tyrosine kinase regulation and substrate recognition

10:30 – Jack Bauer, Evolution of Origin Recognition in Eukaryotes

10:45 – Anthony Bogetti, The Next Frontier in Protein Structure Prediction: Pathways and Kinetics

11:00 – Anthony Chesebro, SciML Derived Neural Mass Models for Data-Driven Circuit Discovery

11:15 – Julia Gattozzi, Dissecting cellular heterogeneity and clonal dynamics in castration resistant prostate cancer

11:30 – Alejandro Gil Gomez, Assembly of the Aminocoumarin Biosynthetic Pathway Sparked an Evolutionary Arms Race

11:45 - Alyssa Kerning, Targeted degradation of brutons tyrosine kinase

Lunch 12:00 – 1:00 pm (Group Photo)

Afternoon Session I 1:15 – 2:15 pm

1:15- Charles Kocher, Eusocial Reproduction Selects for Longevity

1:30- Rafał Krzysztoń, Sense-response system for conditional mRNA expression in mammalian cells

1:45- Isabelle Kwan, Essential Interfaces: How Complexation Alters Structure-Dynamics

2:00- Steven Pak, Expanding the Fragment Library for De Novo Design with DOCK6 via isosteric swapping

2:15 – 2:45 Coffee Break (and Poster set up)

Afternoon Session II 2:45– 3:45 pm

2:45- Sukrit Singh, Prospective Evaluation of Structure-Based Simulations Reveal Their Ability to Predict the Impact of Kinase Mutations on Inhibitor Binding

3:00- Pallavi Surana, Pan cancer transcriptome disruptions at tissue-specificity and isoform-level

3:15- Aslam Uddin, Aggregation Propensity of Conformationally Constrained Alpha Synuclein 

3:30- Ying-Jen Yang, Deriving the Forces of Nonequilibria from Two Laws

Poster Presentations 3:45 – 5:00

Awards Ceremony 5:15 – 5:30 (awards for 2 postdocs, 2 grad students, 2 posters)

Buffet Dinner 5:30-7:00